Restylane Defyne and Restylane Refyne

Injectable fillers have been a major innovation in cosmetic care. Dermal fillers provide non-surgical anti-aging techniques that really work. After a single treatment, with little to no downtime**, fillers can give the face a smoother, fresher, more youthful appearance.

The late breaking news in the world of dermal injectable products is that the FDA has approved two new fillers for release in early 2017 – Restyle Defyne and Restylane Refyne. These fillers are specially designed to minimize laugh lines in a way that supports the patient’s natural expression.

At Procerus Skin Care in Ann Arbor, Michigan, Dr Gilmore a Galderm Aesthetic Injectables Trainer was amongst the select few physcians flown down to Dallas by Galderma for their Train the Trainers Session introducing Restylane Defyne and Restylane Refyne. In Dr Gilmore’s hands, she applies dermal fillers with a customized approach to help rejuvenate and enhance your natural appearance in a subtle fashion.

Your face will never look “done,” and injectable filler treatments can give you a more youthful appearance with immediate results at a fraction of the cost of surgery, and without the associated risks and downtime.**

**The results may vary for different people.


These two new products from Galderma have been called “next-generation” hyaluronic acid fillers. Hyaluronic acid (HA) is a substance that occurs naturally in the body, binds to water, and retains moisture in the skin. It fills in the spaces between fibers of collagen and elastin and plumps up the skin for a more youthful look.

Unlike other Hyaluronic acid fillers, Restylane Defyne and Restylane Refyne incorporate new “XpresHAn” technology, which allows for movement of the fillers within the face with any facial expression, resulting in a more natural appearance.

Whether you are laughing, smiling, frowning, or making any expression that causes the face to wrinkle, these HA (Hyaluronic acid) gels can flex within your skin for a look that is soft, natural, and never stiff.

This unique characteristic makes Restylane Defyne and Restylane Refyne particularly suitable for the treatment of laugh lines. These products are both designed and FDA approved for mid to deep injection into the facial tissue to correct facial wrinkles and folds. Although they are being newly introduced in the U.S., they have been approved and used in Europe since 2010 under the name “Emervel.”


Both new Restylane fillers – Defyne and Refyne – are hyaluronic acid products using XpresHAn technology that allows them to flex within the skin along with your facial expressions for a soft, natural result.

As stated by the manufacturer, Galderma, Restylane Refyne is for the treatment of moderate to severe wrinkles and folds in the face, such as nasolabial folds – the lines that run vertically from the nostrils to the corners of the mouth.

Restylane Defyne is designed to treat moderate to severe deep facial folds and wrinkles, including nasolabial folds. Which product is appropriate for treatment will depend on the depth of the lines and wrinkles to be treated. Depending on the patient, a combination of both fillers may be appropriate for use in just one treatment session.

At Procerus Skin Care, we offer cutting-edge facial fillers to help you achieve the smoother, fresher, natural result you want. If you would like to find out if Restylane Defyne and Restylane Refyne injectable fillers are the right treatment option for you, contact us to schedule a consultation in our Ann Arbor office.

How much does Restylane Defyne cost?

Price Range: $475-$775

How much does Restylane Refyne cost?

Price Range: $475-$775